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Stock comparison · Signal date 2026-11-06

PTGX vs SYRE: stock comparison and AI forecast

Protagonist Therapeutics, Inc (PTGX) and Spyre Therapeutics, Inc. (SYRE) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

PTGX Protagonist Therapeutics, Inc

Market Cap
$8.75B
P/E Ratio
171.2x
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

SYRE Spyre Therapeutics, Inc.

Market Cap
$8.52B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

PTGX · SYRE

Key facts

  • PTGX and SYRE have similar market capitalizations ($8.75B and $8.52B).
  • PTGX carries 0.05 times debt per unit of equity, against 0.05 times for SYRE.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricPTGXSYRE
Market Cap$8.75B$8.52B
P/E Ratio171.21x–
P/B Ratio10.40x8.10x
EPS$0.79$-2.19
Book Value/Share$13.01$11.93
Revenue/Share$3.49–
FCF/Share$2.02–

Profitability & Margins

MetricPTGXSYRE
ROE–-25.1%
ROA–-24.0%
ROIC6.9%-23.6%
Operating Margin25.9%–
EBT Margin36.4%–
Tax Rate1.7%0.0%

Financial Health

MetricPTGXSYRE
Current Ratio21.71x27.40x
D/E Ratio0.05x0.05x
Financial Leverage1.05x1.05x
Working Capital$770M$1.06B

Cash Flow

MetricPTGXSYRE
Operating Cash Flow$131M-$249M
Free Cash Flow$131M–
Capital Spending-$610K–
OCF Growth YoY231.8%–
FCF Growth YoY252.0%–
FCF/Sales57.9%–
CapEx/Sales0.3%–

Operational Efficiency

MetricPTGXSYRE
Asset Turnover0.25x–
Fixed Assets Turnover65.3x–

Income Statement

MetricPTGXSYRE
Total Revenue$226M–
Operating Income$58M-$250M
Net Income–-$264M
R&D Expense$175M$260M

Dividend & Shareholder Information

MetricPTGXSYRE
Shares Outstanding65M88M
EPS Growth-14.1%–
FAQ

PTGX vs SYRE: stock comparison and AI forecast

Which is bigger, PTGX or SYRE?

PTGX and SYRE have similar market capitalizations ($8.75B and $8.52B).

Which one does Intratio's AI model rank higher, PTGX or SYRE?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.