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Stock comparison · Signal date 2026-11-06

SYRE vs TGTX: stock comparison and AI forecast

Spyre Therapeutics, Inc. (SYRE) and Tg Therapeutics, Inc. (TGTX) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

SYRE Spyre Therapeutics, Inc.

Price
$96.59 +32.1% · 6M
Market Cap
$8.52B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

TGTX Tg Therapeutics, Inc.

Price
$57.98 +34.8% · 6M
Market Cap
$9.20B
P/E Ratio
21.9x
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

6M · 2026-05-07 → 2026-11-06

Six-month price performance

Closing prices rebased to 100 at the start of the window.

90105120135150
SYRE +32.1% TGTX +34.8%
SYRE · TGTX

Key facts

  • SYRE and TGTX have similar market capitalizations ($8.52B and $9.20B).
  • Over the last six months TGTX returned +34.8% and SYRE +32.1%.
  • TGTX carries 1.71 times debt per unit of equity, against 0.05 times for SYRE.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricSYRETGTX
Market Cap$8.52B$9.20B
P/E Ratio–21.88x
P/B Ratio8.10x15.23x
EPS$-2.19$2.65
Book Value/Share$11.93$3.81
Revenue/Share–$5.04
FCF/Share–$0.11

Profitability & Margins

MetricSYRETGTX
ROE-25.1%73.1%
ROA-24.0%26.9%
ROIC-23.6%9.9%
Gross Margin–82.4%
Operating Margin–17.1%
Net Margin–55.2%
EBT Margin–12.7%
Tax Rate0.0%-334.5%

Financial Health

MetricSYRETGTX
Current Ratio27.40x4.27x
Quick Ratio–3.72x
D/E Ratio0.05x1.71x
Financial Leverage1.05x2.71x
Interest Coverage–1.2x
Working Capital$1.06B$877M

Cash Flow

MetricSYRETGTX
Operating Cash Flow-$249M$18M
Free Cash Flow–$17M
Capital Spending–-$490K
FCF/Sales–2.2%
CapEx/Sales–0.1%

Operational Efficiency

MetricSYRETGTX
Asset Turnover–0.49x
Receivables Turnover–2.0x
Inventory Turnover–0.9x
Days Sales Outstanding–183 days
Days Inventory–383 days

Income Statement

MetricSYRETGTX
Total Revenue–$800M
Operating Income-$250M$136M
Net Income-$264M$441M
R&D Expense$260M$226M
SG&A Expense–$296M
Cost of Goods Sold–$141M

Dividend & Shareholder Information

MetricSYRETGTX
Shares Outstanding88M159M
Net Income Growth–630.2%
EPS Growth–846.4%
FAQ

SYRE vs TGTX: stock comparison and AI forecast

Which is bigger, SYRE or TGTX?

SYRE and TGTX have similar market capitalizations ($8.52B and $9.20B).

Which stock performed better over the last six months, SYRE or TGTX?

Over the last six months TGTX returned +34.8% and SYRE +32.1%.

Which one does Intratio's AI model rank higher, SYRE or TGTX?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.