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Stock comparison · Signal date 2026-11-06

PFE vs VRTX: stock comparison and AI forecast

Pfizer Inc (PFE) and Vertex Pharmaceuticals Inc / Ma (VRTX) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
NYSE · Pharmaceutical Preparations

PFE Pfizer Inc

Market Cap
$170.31B
P/E Ratio
37.8x
Size
large-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

VRTX Vertex Pharmaceuticals Inc / Ma

Price
$542.50 +26.9% · 6M
Market Cap
$137.50B
P/E Ratio
34.9x
Size
large-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

PFE · VRTX

Key facts

  • PFE is 1.2 times larger than VRTX by market capitalization ($170.31B against $137.50B).
  • VRTX trades at 34.9 times trailing earnings, PFE at 37.8 times.
  • VRTX turns 30.7% of its revenue into net income, against 6.3% for PFE.
  • PFE carries 1.29 times debt per unit of equity, against 0.57 times for VRTX.
  • PFE yields 5.75% in dividends; VRTX pays none.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricPFEVRTX
Market Cap$170.31B$137.50B
P/E Ratio37.82x34.93x
P/B Ratio1.91x6.58x
Dividend Yield5.75%–
EPS$0.79$15.53
Book Value/Share$15.62$82.49
Revenue/Share$11.16$51.10
FCF/Share$2.07$12.63

Profitability & Margins

MetricPFEVRTX
ROE4.5%19.0%
ROA2.0%12.2%
ROIC–15.5%
Gross Margin73.4%85.5%
Operating Margin–33.2%
Net Margin6.3%30.7%
EBT Margin6.7%36.8%
Tax Rate4.4%16.5%

Financial Health

MetricPFEVRTX
Current Ratio1.42x2.34x
Quick Ratio1.10x1.89x
D/E Ratio1.29x0.57x
Financial Leverage2.30x1.57x
Interest Coverage–245.8x
Working Capital$13.28B$6.69B

Cash Flow

MetricPFEVRTX
Operating Cash Flow$14.17B$3.69B
Free Cash Flow$11.79B$3.20B
Capital Spending-$2.39B-$492M
OCF Growth YoY8.4%-0.6%
FCF Growth YoY13.6%-4.0%
FCF/Sales18.5%24.7%
CapEx/Sales3.8%3.8%

Operational Efficiency

MetricPFEVRTX
Asset Turnover0.31x0.40x
Receivables Turnover4.5x5.6x
Inventory Turnover1.7x0.8x
Fixed Assets Turnover3.3x7.6x
Days Sales Outstanding81 days65 days
Days Inventory216 days437 days
Payables Period88 days92 days
Cash Conversion Cycle210 days410 days

Income Statement

MetricPFEVRTX
Total Revenue$63.62B$12.95B
Operating Income–$4.30B
Net Income$4.03B$3.98B
R&D Expense$11.52B$4.25B
SG&A Expense$13.81B$2.41B
Cost of Goods Sold$16.94B$1.87B

Dividend & Shareholder Information

MetricPFEVRTX
Dividends Per Share$1.72–
Payout Ratio217.7%–
Shares Outstanding5700M253M
Net Income Growth-59.0%8.2%
EPS Growth-55.1%8.6%
FAQ

PFE vs VRTX: stock comparison and AI forecast

Which is bigger, PFE or VRTX?

PFE is 1.2 times larger than VRTX by market capitalization ($170.31B against $137.50B).

Which is cheaper on earnings, PFE or VRTX?

VRTX trades at 34.9 times trailing earnings, PFE at 37.8 times.

Which one does Intratio's AI model rank higher, PFE or VRTX?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.